Journal article
A control experiment for studies that show improved visual sensitivity with intraocular pressure lowering in glaucoma
AJ Anderson, MJ Stainer
Ophthalmology | ELSEVIER SCIENCE INC | Published : 2014
Abstract
Purpose: Contrast sensitivity sometimes increases in patients with open-angle glaucoma when intraocular pressure (IOP) is decreased. Although often interpreted as demonstrating reversible glaucoma-induced dysfunction, this result, if true, could simply reflect a general relationship between sensitivity and IOP in visual mechanisms unaffected by glaucoma. To investigate this relationship, we test the hypothesis that reducing IOP in eyes without glaucoma (ocular hypertension) does not increase perimetric contrast sensitivity.Design: Comparative case series.Participants: A total of 692 participants drawn from the Ocular Hypertension Treatment Study (OHTS) (22 clinical centers).Methods: Commerci..
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Awarded by National Eye Institute
Funding Acknowledgements
Supported by Australian Research Council Future Fellowship FT120100407 (A.J.A.). The original OHTS was supported by awards from the National Eye Institute, National Center on Minority Health and Health Disparities, National Institutes of Health (Grants EY09341, EY09307), Horncrest Foundation, awards to the Department of Ophthalmology and Visual Sciences at Washington University, the National Institutes of Health Vision Core Grant P30 EY 02687, Merck Research Laboratories, Pfizer, Inc. (Whitehouse Station, NJ), and unrestricted grants from Research to Prevent Blindness, Inc (New York, NY).